In the light of the continuous efforts exerted by the National Water Research Center (NWRC) affiliate research institutes to take advance in scientific research, an esteemed research team comprising Dr. Walaa Salah El-Din Mohamed, Dr. Mohammed Taha Moustafa Hussien Hamad and Dr. Mahmoud Zaky Kamel of the Central Laboratory for Environmental Quality Monitoring (CLEQM) has successfully developed a new eco-friendly technique to optimize fluoride removal using Padina sp. Alga. The research paper entitled: “Application of Statistical Response Surface Methodology for Optimization of Fluoride Removal Efficiency by Padina sp. Alga” was published in the Water Environment Research Journal of the Water Environment Federation. In the present study, the fluoride biosorption was studied using nonliving biomass of Padina sp. alga as biosorbent. The effects of various parameters like pH, time, Fluoride concentration, and biosorbent dose were reported and optimized to obtain the highest removal using conventional optimization by one-factor-at-a-time (OFAT) and response surface methodology (RSM) using Box-Behnken design. It was concluded that the Padina sp. alga could be used as eco-friendly biosorbent for fluoride and response surface methodology was more applicable and effective in optimization to obtain the highest removal efficiency of fluoride by Padina sp.